Bupropion drug class pregnancy

Bupropion is an antidepressant used to treat major depressive disorder and seasonal affective disorder.

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The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Bupropion may also be used for purposes not listed in this medication guide. You should not take bupropion if you are allergic to it, or if you have:. Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion.

A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take bupropion to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking. Bupropion may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether bupropion will harm an unborn baby.

Bupropion Use During Pregnancy: A Systematic Review

However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking bupropion without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Bupropion is not approved for use by anyone younger than 18 years old. Get emergency medical help if you have signs of an allergic reaction hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling.

Report any new or worsening symptoms to your doctorsuch as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physicallymore depressed, or have thoughts about suicide or hurting yourself. This is not a complete list of side effects and others may occur.

Call your doctor for medical advice about side effects. Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can also cause seizures in a regular drinker who suddenly stops drinking at the start of treatment with bupropion. Avoid driving or hazardous activity until you know how this medicine will affect you.

Your reactions could be impaired. Do not use in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Your doctor may occasionally change your dose. Use the medicine exactly as directed.Bupropion is an antidepressant medicine that can also decrease appetite. Naltrexone is usually given to block the effects of narcotics or alcohol in people with addiction problems.

Naltrexone may also curb hunger and food cravings. Bupropion and naltrexone is a combination medicine used to help manage weight in obese or overweight adults with weight-related medical problems. This medicine is used together with diet and exercise. Bupropion and naltrexone will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol. Contrave is not approved to treat depression or other psychiatric conditions, or to help you quit smoking.

Bupropion and naltrexone may also be used for purposes not listed in this medication guide. Do not use this medicine if you are pregnant. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Tell your doctor right away if you become pregnant.

You should not use this medicine if you are allergic to bupropion or naltrexone, or if you have:. Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion and naltrexone.

A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Some young people have thoughts about suicide when first taking bupropion.

Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. This medicine is not approved for use by anyone younger than 18 years old. Get emergency medical help if you have signs of an allergic reaction: fever, swollen glands, mouth sores, muscle or joint pain; hives, rash or itching; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, severe drowsiness, or if you are hard to wake up. This is not a complete list of side effects and others may occur.

Call your doctor for medical advice about side effects. Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can also cause seizures in a regular drinker who suddenly stops drinking.

Follow your doctor's instructions about any restrictions on food, beverages, or activity. Do not take other weight-loss products or diet pills unless your doctor has told you to. Do not use narcotic medication, methadone, heroin, or other street drugs while you are taking bupropion and naltrexone. Doing so could result in dangerous effects, including coma and death. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.This sheet talks about using bupropion in a pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider. Bupropion is a medication used to treat depression and seasonal affective disorder. There are no studies that look specifically at fertility in women taking bupropion. Two cases have been reported of irregular menstrual cycles linked to bupropion use.

However, these case reports did not mention fertility problems. Talk with your healthcare provider s before making any changes to this medication. For some women, the benefits of staying on an antidepressant during pregnancy may outweigh the potential risks. People who suddenly stop taking their antidepressant are at risk for withdrawal. Symptoms of withdrawal can include: dizziness, upset stomach, trouble sleeping, and nervousness or anxiety. Miscarriage may occur in any pregnancy.

Two studies did not find a higher rate of miscarriage among women taking bupropion compared to the background rate for miscarriage in the general population. Does taking bupropion in the first trimester increase the chance of birth defects? This is called her background risk.

One study has suggested a weak association between first trimester exposure and heart defects. The design of this study does not allow a conclusion to be drawn.

In contrast, other studies involving over 2, pregnancies exposed to bupropion in the first trimester showed no increase in the chance for birth defects. Therefore, it is unlikely that using bupropion during pregnancy would increase the chance for birth defects over the background risk.

bupropion drug class pregnancy

Does taking bupropion in the second or third trimester cause other pregnancy complications? In a small study of 30 women who were given bupropion for 12 weeks to help them quit smoking during pregnancy, no differences in birth weight, length, head circumference, or Apgar score were seen. I need to take bupropion throughout my entire pregnancy.

Can it cause withdrawal symptoms in my baby? Some infants whose mothers took other antidepressants near the end of pregnancy have had withdrawal symptoms like irritability, jitteriness, sleep disturbances, or eating difficulties. Does taking bupropion during pregnancy cause long-term problems in behavior or learning for the baby? There is very little known about long term effects on children exposed to bupropion during pregnancy. One study has suggested an association between prenatal exposure to bupropion and attention deficit hyperactivity disorder ADHD.Drugs are used in over half of all pregnancies, and prevalence of use is increasing.

The most commonly used drugs include antiemetics, antacids, antihistamines, analgesics, antimicrobials, diuretics, hypnotics, tranquilizers, and social and illicit drugs. Despite this trend, firm evidence-based guidelines for drug use during pregnancy are still lacking. However, few well-controlled studies of therapeutic drugs have been done in pregnant women. Most information about drug safety during pregnancy is derived from animal studies, uncontrolled studies, and postmarketing surveillance.

bupropion drug class pregnancy

Consequently, the FDA classification system led to confusion and difficulty applying available information to clinical decisions. Instead of categories, the FDA now requires that labeling provide information about the specific drug in a consistent format called the final rule. Pregnancy: Information relevant to the use of the drug in pregnant women eg, dosing, fetal risks and information about whether there is a registry that collects and maintains data on how pregnant women are affected by the drug.

bupropion drug class pregnancy

Lactation: Information about using the drug while breastfeeding eg, the amount of drug in breast milk, potential effects on the breastfed child. Females and males of reproductive potential: Information about pregnancy testing, contraception, and infertility as it relates to the drug. The pregnancy and lactation subsections each include 3 subheadings risk summary, clinical considerations, and data that provide more detail.

During pregnancy, drugs are often required to treat certain disorders. In general, when potential benefit outweighs known risks, drugs may be considered for treatment of disorders during pregnancy.

Not all maternal drugs cross the placenta to the fetus. Drugs that cross the placenta may have a direct toxic effect or a teratogenic effect. Drugs that do not cross the placenta may still harm the fetus by. More information on a particular drug can be obtained from the. Drugs diffuse across the placenta similarly to the way they cross other epithelial barriers see Drug Absorption. Substances with a high molecular weight eg, protein-bound drugs usually do not cross the placenta.

One exception is immune globulin G, which may be used to treat disorders such as fetal alloimmune thrombocytopenia. Generally, equilibration between maternal blood and fetal tissues takes at least 30 to 60 min; however, some drugs do not reach similar concentrations in the maternal and fetal circulation. Before the 20th day after fertilization: Drugs given at this time typically have an all-or-nothing effect, killing the embryo or not affecting it at all. Teratogenesis is unlikely during this stage.

During organogenesis between 20 and 56 days after fertilization : Teratogenesis is most likely at this stage. Drugs reaching the embryo during this stage may result in spontaneous abortion, a sublethal gross anatomic defect true teratogenic effectcovert embryopathy a permanent subtle metabolic or functional defect that may manifest later in lifeor an increased risk of childhood cancer eg, when the mother is given radioactive iodine to treat thyroid cancer ; or the drugs may have no measurable effect.

After organogenesis in the 2nd and 3rd trimesters : Teratogenesis is unlikely, but drugs may alter growth and function of normally formed fetal organs and tissues.Bupropionsold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support smoking cessation. Common side effects of bupropion include a dry mouthdifficulty sleeping, agitation, and headaches.

Bupropion is an atypical antidepressant.

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Bupropion was first made by chemist Nariman Mehta inand patented by Burroughs Wellcome in A meta-analysis found only weak evidence supporting use of bupropion for depression, with only a few available trials; and the little evidence that was available showed that bupropion had a weak antidepressant effect.

Bupropion was approved by the U. Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction. The addition to a prescribed SSRI is a common strategy when people do not respond to the SSRI, even though this is not an officially approved indication. Bupropion is prescribed as an aid for smoking cessation. Animal studies indicate that administration of bupropion at less than the recommended therapeutic dose may actually enhance the rewarding properties of nicotine, i.

It is uncertain whether bupropion is safe or effective for treatment of ADHD in children. Its effect may also be "considerably less than of the approved agents Thus it may be prudent for the clinician to recommend a trial of behavior therapy at this point, before moving to these second-line agents.

It is also uncertain whether bupropion is safe or effective for treatment of ADHD in adults, as the available evidence comparing bupropion to placebo for treatment of ADHD is of low-quality. Bupropion is less likely than other antidepressants to cause sexual dysfunction.

There have also been several studies suggesting that bupropion can improve sexual function in women who are not depressed, if they have hypoactive sexual desire disorder HSDD. Bupropion, when used for treating obesity over a period of 6 to 12 months, may result in weight loss of 2. There has been controversy about whether it is useful to add an antidepressant such as bupropion to a mood stabilizer in people with bipolar depressionbut recent reviews have concluded that bupropion in this situation does no significant harm and may sometimes give significant benefit.

The drug label advises that bupropion should not be prescribed to individuals with epilepsy or other conditions that lower the seizure thresholdsuch as anorexia nervosabulimia nervosabenzodiazepine abuse or withdrawal, and alcohol abuse or withdrawal.

It should be avoided in individuals who are also taking monoamine oxidase inhibitors MAOIs.Send the page " " to a friend, relative, colleague or yourself. We do not record any personal information entered above. The safety and efficacy of bupropion for smoking cessation is not established in children or adolescents. Children 6 years and older with a major depressive episode or attention-deficit hyperactivity disorder ADHD have been studied in clinical trials of bupropion, but data regarding pediatric safety are limited.

When bupropion is used for the treatment of ADHD in pediatrics, careful screening and monitoring is recommended by the American Heart Association. In Octoberthe FDA directed manufacturers of all antidepressants to include a boxed warning detailing the risk of suicide in pediatric patients.

bupropion drug class pregnancy

The analysis showed a greater risk of suicidality during the first few months of treatment in those receiving antidepressants. Pooled analysis of short-term clinical trials during early phase treatment with antidepressants in young adults 18 to 24 years also showed an increased risk of suicidal thinking and behavioral changes. The clinical need for an antidepressant in pediatrics or young adults for any use must be weighed against the risk of increased suicidality; patients who are started on therapy should be observed closely for clinical worsening, suicidality, or behavioral changes, particularly within the first few months of starting therapy or during dose adjustments.

It is unknown if the suicidality risk in children and young adults extends to longer-term therapy. The possibility of a suicide attempt is inherent in any patient with depressive symptoms, whether these occur in a primary depressive episode or in association with another primary disorder such as OCD.

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In patients who exhibit adverse changes in symptoms, worsening of depressive symptoms, or suicidality, a decision should be made to change or discontinue treatment. If discontinuing bupropion, the medication should be tapered as rapidly as possible, but with recognition that discontinuing treatment abruptly can also cause adverse symptoms.

Bupropion should be prescribed in the smallest quantity consistent with good patient management in order to reduce the risk of overdose. Oral antidepressant of the aminoketone class; unrelated to other antidepressants Brand-specific FDA approvals for major depression, seasonal affective disorder, and smoking cessation in adults Greater potential for causing seizures than many other antidepressants; a boxed warning exists for use in pediatric depression.

Initially, mg PO twice daily; titrate after no less than 3 days to mg PO 3 times per day if needed; no single dose should exceed mg. The onset of antidepressant effects takes 1 to 3 weeks, maximal effect may not be noted for 4 weeks. Generally, acute episodes of depression require several months of sustained pharmacologic Reassess the patient periodically to determine the individual need for continued treatment. Use the lowest dosage that maintains remission.

Dosage not established. Suggested dosage ranges from 1. Safety data are not extensive; most patients have also been diagnosed with ADHD. Initially, mg PO once daily in the morning; titrate after no less than 4 days to mg PO twice daily if needed.Bupropion is a prescription medication used to treat depression, prevents seasonal depression, and to quit smoking, depending on the form.

Bupropion belongs to a group of drugs called antidepressants, which work by affecting certain natural chemicals in the brain.

It is not known how bupropion helps patients quit smoking. This medication comes in immediate release tablets, sustained-release tablets, and extended-release tablets.

The immediate release tablets are usually taken 3 or 4 times daily.

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The sustained-release tablet is usually taken twice daily. The extended-release tablet is usually taken once daily. Common side effects of bupropion include nervousness, constipation, trouble sleeping, headache, and nausea.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Wellbutrin (Bupropion)

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:. This is not a complete list of all drug interactions of bupropion. Ask your doctor for more information. What is the most important information I should know about this medication, depression, and other serious mental illnesses, and suicidal thoughts or actions?

What else do I need to know about this bupropion when being treated for depression? Some people have had changes in behavior, hostility, agitation, depression, suicidal thoughts or actions while taking bupropion to help them quit smoking. These symptoms can develop during treatment with bupropion or after stopping treatment with bupropion.

If you, your family member, or your caregiver notice agitation, hostility, depression, or changes in thinking or behavior that are not typical for you, or you have any of the following symptoms, stop taking bupropion and call your healthcare provider right away:.

When you try to quit smoking, with or without bupropion, you may have symptoms that may be due to nicotine withdrawal, including urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, and increased appetite or weight gain.

Some people have even experienced suicidal thoughts when trying to quit smoking without medication. Sometimes quitting smoking can lead to worsening of mental health problems that you already have, such as depression. Before taking bupropion, tell your healthcare provider if you have ever had depression or other mental illnesses. You should also tell your doctor about any symptoms you had during other times you tried to quit smoking, with or without bupropion.

Do not drink a lot of alcohol while taking bupropion. If you usually drink a lot of alcohol, talk with your doctor before suddenly stopping. If you suddenly stop drinking alcohol, you may increase your risk of having seizures. Do not drive a car or use heavy machinery until you know how bupropion affects you.

Bupropion can impair your ability to perform these tasks.

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Medicines can interact with certain foods.


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